Bjorn Fortuin, Zubayr Hamza, Duanne Olivier, Ryan Rickelton and Khaya Zondo are all set to feature in the second match of the series at Willowmoore Park in Benoni from 11-26 December.
Rickelton was a notable omission from the Proteas Test squad to face India.
Matthew Breetzke, who is currently in the Proteas T20I squad, will captain SA A in the second match.
The squad for the first match at the JB Marks Oval in Potchefstroom from 11-14 December will be led by former SA U19 captain Bryce Parsons.
South Africa A squad (first match): Bryce Parsons (c, Dolphins), Eathan Bosch (Dolphins), Junaid Dawood (Lions), Jean du Plessis (Badgers), Rubin Hermann (Dragons), Connor Esterhuizen (Lions), Evan Jones (Lions), Kurtlyn Mannikam (Tuskers), Odirile Modimokoane (Dolphins), Hlompho Modimokoane (Dragons), Siya Plaatjie (Warriors), Cameron Shekleton (Tuskers), Yaseen Valli (Tuskers).
South Africa A squad (second match): Matthew Breetzke (c, Warriors), Bjorn Fortuin (Lions), Zubayr Hamza (Lions), Tshepo Moreki (Lions), Duanne Olivier (Lions), Sinethemba Qeshile (Warriors), Josh Richards (Lions), Ryan Rickelton (Lions), Jason Smith (Dolphins), Johan van Dyk (Heat), Khaya Zondo (Dolphins). Players 12 and 13 TBC.
