Proteas skipper Temba Bavuma has won the toss and decided to bowl first as the Proteas made seven changes for the deciding ODI against Pakistan.
The South Africans were dealt a big blow ahead of play when Cricket South Africa confirmed that Rassie van der Dussen will miss the encounter due to injury.
The right-hander has been impressive throughout the series, scoring 123* and 60, respectively, in the first two matches.
The Proteas are also without Quinton de Kock, David Miller, Kagiso Rabada, Lungi Ngidi and Anrich Nortje for the deciding clash, due to their IPL responsibilities.
Janneman Malan, Jon-Jon Smuts and Kyle Verreynne come into the side for De Kock, Van der Dussen and Miller.
As expected from bowling coach Charl Langeveldt’s comments on Tuesday, Daryn Dupavillon replaces Nortje for what will be only his second ODI for the Proteas.
Lutho Sipamla and Beuran Hendricks complete the pace attack, while Keshav Maharaj gets the nod as spinner ahead of Tabraiz Shamsi.
Heinrich Klaasen will do duty behind the stumps in the absence of De Kock.
Proteas: Janneman Malan, Aiden Markram, Jon-Jon Smuts, Temba Bavuma (c), Kyle Verreynne, Heinrich Klaasen (wk), Andile Phehlukwayo, Keshav Maharaj, Beuran Hendricks, Daryn Dupavillon, Lutho Sipamla.
Pakistan: Imam-ul-Haq, Fakhar Zaman, Babar Azam (c), Mohammad Rizwan, Sarfraz Ahmed, Muhammad Nawaz, Faheem Ashraf, Hassan Ali, Shahen Afridi, Usman Qadir, Haris Rauf.