Donavon Ferreira hit an unbeaten 55 off 29 balls as the Titans beat South Western Districts by 54 runs in the first T20 Knock Out quarter-final in Kimberley.
South Western Districts and Western Province have progressed to the quarter-finals of the T20 Knock Out tournament.
The Lions claimed their second win of the T20 Knock Out after beating South Western Districts by four wickets at the Kimberley Oval on Sunday.
Yaseen Valli carried his bat as South Western Districts beat Western Province by three wickets with two balls to spare in a nail-biting T20 Knock Out match in Kimberley on Saturday.
Jean du Plessis and Heath Richards showed sublime batting form to guide South Western Districts to a 24-run victory over the Northern Cape Heat in their T20 Knock Out match in Kimberley on Friday.
Northerns ended their Africa T20 Cup Pool B campaign on a high, despite being knocked out of the tournament.