South Africa have won the toss and have sent India in to bat in the second T20I at SuperSport Part in Centurion.
The Proteas are unchanged for the must-win game, while India have made just one change with Jasprit Bumrah making way for Shardul Thakur.
South Africa will be hoping to turn the series around with a win, but much will depend on the weather as rain is expected in Centurion.
Earlier on Wednesday, the fourth T20I between the Proteas women and India was abandoned due to rain.
South Africa: Reeza Hendricks, Jon-Jon Smuts, JP Duminy (captain), David Miller, Farhaan Behardien, Heinrich Klaasen, Andile Phehlukwayo, Chris Morris, Dane Paterson, Junior Dala, Tabraiz Shamsi
India: Rohit Sharma, Shikhar Dhawan, Suresh Raina, Virat Kohli (captain), Manish Pandey, MS Dhoni, Hardik Pandya, Bhuvneshwar Kumar, Jaydev Unadkat, Yuzvendra Chahal, Shardul Thakur.