Lizelle Lee’s 117 was not enough as the Proteas Women failed to chase down 332, resulting in England levelling the series 1-1 with a 69-run victory in Brighton.
Centuries from Tammy Beaumont and Sarah Taylor powered the England Women to 331-6 in their 50 overs in the second ODI in Brighton.
The Proteas Women put in an exquisite bowling performance to reduce England to 189-9 in the first ODI in Worcester.
The three England women in Wisden’s five Cricketers of the Year have been named in a squad of 14 for the first two ODIs of the summer, against South Africa at Worcestershire and Hove.
The Proteas Women will tour England in 2018 from 9 June until 1 July.
A record 275-run stand between Sarah Taylor and Tammy Beaumont laid the foundation for a comprehensive 68-run England victory over the Proteas on Thursday.
England fell 35 runs short of victory against India in the Women’s World Cup curtain-raiser on Saturday.
Trisha Chetty is on a roll, scoring 66 in the second ODI to help the Proteas women level the three-match series against England at 1-1.
England’s women followed in the path blazed by the men by beating South Africa by seven wickets, on the D/L calculation, in the first of three ODIs, in Benoni on Sunday.