South Africa will field first after winning the toss in the third and final T20I at Newlands in Cape Town.
The Proteas made two changes to the team that won the second T20I at SuperSport Park in Centurion on Wednesday.
Jon-Jon Smuts and Dane Paterson made way for Aaron Phangiso and Christiaan Jonker.
India are without captain Virat Kohli (stiff back), Yuzvendra Chahal and Jaydev Unadkat, and they have been replaced by Dinesh Karthik, Axar Patel and Jasprit Bumrah.
South Africa: D Miller, R Hendricks, JP Duminy, H Klaasen, F Behardien, C Jonker, C Morris, A Phehlukwayo, A Phangiso, J Dala, T Shamsi
India: RG Sharma, S Dhawan, S Raina, M Pandey, MS Dhoni, D Karthik, H Pandya, A Patel, B Kumar, S Thakur, J Bumrah