Heinrich Klaassen’s unbeaten century propelled the Proteas to a 107-run win over the England Lions in Worcester on Thursday.
The 30-year-old scored 123 off 85 balls and received good support from Rassie van der Dussen (61 off 52) and Andile Phehlukwayo (67 off 53) as the Proteas posted 360-7 in their 50 overs.
Tabraiz Shamsi then took 3-66, and Keshav Maharaj, Lungi Ngidi and Anrich Nortje two wickets each as the England Lions were bowled out for 253 in 38.2 overs.
Opener Stephen Eskinazi top-scored for the hosts with 79 off 74 balls.
This match had List-A status, unlike Tuesday’s first match between the teams (won by the England Lions) in which the Proteas gave all 17 squad members game time.
The first ODI of the three-match series between England and the Proteas will take place at the Riverside Ground in Chester-le-Street on Tuesday.