Holder made 54* with six fours and one six and shared a key last-wicket partnership of 40 with Shamar Joseph (25).
The West Indies resumed on their overnight score of 97-7 in reply to the Proteas’ 160 all out in their first innings after an opening day which saw 17 wickets fall.
Medium pacer Wiann Mulder took 4-32 for South Africa with fast bowler Nandre Burger claiming 3-49.
The first Test of the two-game series ended in a rain-affected draw in Trinidad.
© Agence France-Presse
Photo: Daniel Prentice/Gallo Images
