Kagiso Rabada and Kyle Abbott replace Marchant de Lange and Chris Morris but South Africa will bat first in the second ODI against England.
Rabada was rested for the first game in Bloemfontein but returns to give the bowling attack plenty of pace, bounce and control.
Abbott is back from injury and together with Rabada they should ensure that the bowling is more disciplined after the massacre in Bloemfontein where England scored 399.
AB de Villiers won the toss and decided to bat first.
South Africa: Quinton de Kock, Hashim Amla, Faf du Plessis, AB de Villiers, JP Duminy, Rilee Rossouw, Farhaan Behardien, Kyle Abbott, Kagiso Rabada, Morne Morkel, Imran Tahir.
England: Jason Roy, Alex Hales, Joe Root, Jos Buttler, Eoin Morgan, Ben Stokes, Moeen Ali, Chris Jordan, Adil Rashid, David Willey, Reece Topley.